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Bacteria like E. coli divide every 20 minutes. But their DNA — about 4.6 million base pairs — takes about 38 minutes to replicate at 2000 base pairs per second. So how do they manage it?

/ Molecular Basis of Inheritance, NCERT LINE BY LINE, pre-class / By Prof. Siddharth Sanghvi

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🧬 The DNA-Time Dilemma

Bacteria like E. coli divide every 20 minutes. But their DNA — about 4.6 million base pairs — takes about 38 minutes to replicate at 2000 base pairs per second. So how do they manage it?

⏳ Evolution’s Clever Hack

Instead of waiting to finish DNA copying, bacteria start early. They initiate the next round of replication before the first is done. This is called multifork replication.

🔁 Multifork Replication in Action

Imagine you’re running a relay race. Just before you finish your lap, the next runner starts running. That’s what bacteria do — they pass the baton before the lap ends.

Multifork Replication Diagram

👩‍👧‍👧 Like Parent, Like Daughter

When the parent cell divides, its daughter cells inherit a chromosome that’s only partially replicated. These daughters don’t just wait — they continue the unfinished job while starting new replication rounds of their own!

🚀 Every Cell a Factory

Each daughter cell is both a finisher (completing replication from the parent) and a starter (initiating new forks). This keeps the cycle efficient and fast, like a nonstop conveyor belt.

📚 Summary: The Time Paradox Solved

Though replication takes 38 minutes, overlapping cycles allow bacteria to divide every 20 minutes. By starting early and sharing the job between generations, nature beats the clock — elegantly and efficiently.

Overlapping Replication Cycles

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